Pair Name	Wilforlide A, Docetaxel
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
	Down-regulation	Expression	CDKN1A	hsa1026
In Vitro Model	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
	DU145	Prostate carcinoma	Homo sapiens (Human)	CVCL_0105
In Vivo Model	These PC3-TxR cells were suspended in a 1:1 mixture of Matrigel and RPMI 1640 and subcutaneously implanted into planks of mice via injection.
Result	Wilforlide A was found to enhance the chemosensitizing effect of docetaxel both in vitro and in vivo. Further studies are warranted to verify wilforlide A as a new drug candidate to overcome docetaxel resistance in prostate cancer.